Troglitazone, a PPAR agonist, inhibits human prostate cancer cell ...

Authors: Ban JO, Oh JH, Son SM, Won D, Song HS, Han SB, Moon DC, Kang KW, Song MJ, Hong JT
PPAR? ligands have been reported to reduce proliferation of human prostate cancer cells. However, the molecular mechanism of PPAR??agonist-induced cell growth inhibition of prostate cancer cells is not clear. GSK-3b expression and NF-kB activity have important roles in prostate cancer development. To investigate the mechanisms of the PPAR??agonist-induced prostate cancer cell growth inhibition, we examined the effect of troglitazone on the expression of PPAR?, GSK-3b?and activity of NF-kB as well as on the prostate cancer cell growth. Troglitazone induced the expression of PPAR? in the nuclear of PC-3 cells, but not in LNCaP cells. Troglitazone (0-16 uM) inhibited cancer cell growth in?
MedWorm: Biology

Source: http://plosbiology.buzzingbee.org/2011/05/30/troglitazone-a-ppar-agonist-inhibits-human-prostate-cancer-cell-growth-through-inactivation-of-nf-kb-via-suppression-of-gsk-3i%C2%B2-expression/

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